บทคัดย่องานวิจัย

หมวดหมู่ : ฐานข้อมูลงานวิจัย

Regulation of fumonisin B1 biosynthesis and conidiation in Fusarium verticillioides by a cyclin – like (C-type) gene, FCC1.

SHIM, W.B. and WOLOSHUK, C.P.

Applied and Environmental Microbiology 67: 1607 – 1612.

2001

บทคัดย่อ

Regulation of fumonisin B1 biosynthesis and conidiation in Fusarium verticillioides by a cyclin – like (C-type) gene, FCCI.

A mutant of Fusarium verticillioides, FT536, carrying a disrupted gene named FCC1 (for Fusarium cyclin C1) resulting in altered FB1 biosynthesis has been generated. FCC1 contains an open reading frame of 1,018 bp, with one intron, and encodes a putative 319 – amino – acid polypeptide. When strain FT536 was grown on corn kernels or on defined minimal medium at pH 6, conidiation was reduced and FVM5, the polyketide synthase gene involved in FB1 biosynthesis, was not expressed. However, when the mutant was grown on a defined minimal medium at pH3, conidiation was restored, and the blocks in expression of FUM5 and FB1 production were suppressed. Our data suggest that FCC1 plays an important role in signal transduction regulating secondary metabolism (fumonism biosynthesis) and fungal development (conidiation) in F.verticillioides.